A4262
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A4262
Sigma
Actinomycin D
from Streptomyces sp., ~95% (HPLC)
| Synonym: | Actinomycin C1, Actinomycin IV, Dactinomycin |
| CAS Number: | 50-76-0 |
| Linear Formula: | C62H86N12O16 |
| Molecular Weight: | 1255.42 |
| Beilstein Registry Number: | 605235 |
| EC Number: | 200-063-6 |
| MDL number: | MFCD00005033 |
| PubChem Substance ID: | 24890842 |
Description
| Biochem/physiol Actions | An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes. |
Properties
| biological source | from Streptomyces sp. |
| assay | ~95% (HPLC) |
| color | red, powder |
| mp | 251-253 |
| solubility | ethanol, DMSO: soluble |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T+ |
| Risk Statements | 28 |
| Safety Statements | 22-28-36/37-45 |
| RIDADR | UN3462 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | AU1575000 |
References
| reference | Wadkins, R.M., Actinomycin D binding to single-stranded DNA: sequence specificity and hemi-intercalation model from fluorescence and 1H NMR spectroscopy. J. Mol. Biol. 262, 53, (1996) |
| Hu, B., et al., Kasabach-Merritt syndrome-associated kaposiform hemangioendothelioma successfully treated with cyclophosphamide, vincristine, and actinimycin D. J. Pediatr. Hematol. Oncol. 20, 567, (1998) | |
| Glynn, J.M., et al.,, Apoptosis induced by Actinomycin D, Camptothecin or Aphidicolin can occur in all phases of the cell cycle. Biochem. Soc. Trans. 20, 84S, (1992) | |
| Cohen, S.M., et al., Identification of chromosomal bands replicating early in the S phase of normal human fibroblasts. Exp. Cell Res. 254, 321, (1998) | |
| Verma, R.S., Babu, A. Manual of Basic Techniques New York, NY , (1989) | |
| Chen, H., et al., DNA bending and unwinding associated with actinomycin D antibiotics bound to partially overlapping sites on DNA. J. Mol. Biol. 258, 457, (1996) | |
| Merck | Merck 13,2828 |
| Beilstein | Beil. 27,IV,9642 |
| Aldrich MSDS 1, 34:A / Corp MSDS 1 (1), 62:B / RegBook 1 (2), 2651:C / Sax 6, 134 / Sigma FT-IR 1 (1), 610:D / Structure Index 1, 417:B:6 |
